Description
The combination of amoxycillin and gentamicin acts synergistically against a wide range of infections caused by both Gram-positive (e.g. Staphylococcus, Streptococcus and Corynebacterium spp.) and Gram-negative (e.g. E.coli, Pasteurella, Salmonella and Pseudomonas spp.) bacteria in cattle and swine. Amoxycillin inhibits mainly in Gram-positive bacteria the cross-linkage between the linear peptidoglycan polymer chains that make up a major component
of the cell wall. Gentamicin binds to the 30S subunit of the ribosome of mainly Gram-negative bacteria, thereby interrupting protein synthesis.
Indications
Cattle:
gastrointestinal, respiratory and intramammary infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, diarrhoea, bacterial enteritis, mastitis, metritis and cutaneous abscesses.
Swine:
respiratory and gastrointestinal infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, colibacillosis, diarrhoea, bacterial enteritis and mastitis-metritis-agalactia syndrome (MMA).
Contra indications
Hypersensitivity towards amoxycillin and/or gentamicin.
Administration to animals with a seriously impaired hepatic and/or renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Concurrent administration of nephrotoxic and/or ototoxic preparations, intravenous calcium supplementation, iron supplementation and non-steroidal antiinflammatory preparations.
Side effects
Hypersensitivity reactions.
Dosage
For intramuscular administration. The general dosage is 1 ml per 10 kg body weight per day for 3 days.
Cattle:
30 - 40 ml per animal per day for 3 days.
Calves:
10 - 15 ml per animal per day for 3 days.
Swine:
5 - 10 ml per animal per day for 3 days.
Piglets:
1 - 5 ml per animal per day for 3 days.
Shake well before use. Do not administer more than 20 ml in cattle or more than 10 ml in swine and more than 5 ml in calves per injection site to favour absorption and dispersion.
Withdrawal times
- For meat : 30 days.
- For milk : 2 days.
