Description
Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gramnegative bacteria like E. coli, Haemophilus and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. They disorganise the outer membrane of Gram-negative bacteria by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the anionic lipid A region, thereby neutralising the endotoxin capacity of LPS. Colistin sulphate is poorly absorbed after oral administration, and serum concentrations are generally undetectable. In chickens, residues in serum were detectable for up to 6 hours after administration in the drinking water. Orally administered colistin is eliminated almost totally in faeces.
Indications
Coli-2400 Oral is indicated for gastrointestinal infections caused by colistin sensitive microorganisms like E. coli, Haemophilus and Salmonella spp. in calves, goats, sheep, poultry and swine.
Contra indications
Cases of hypersensitivity to colistin or to any of the excipients.
Administration to animals with seriously impaired renal functions or with an active microbial digestion.
Administration in subtherapeutic doses or in cases of resistance to colistin.
Side effects
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases or mild diarrhoea. Overdoses may result in renal failure.
Dosage
For oral administration.
Calves, goats and sheep:
Twice daily 1 ml per 40 kg body weight for 5 - 7 days.
Poultry and swine:
1 litre per 2000 - 4000 litres of drinking water for 5 - 7 days.
Only sufficient medicated drinking water should be prepared to cover daily requirements.
Medicated drinking water should be replaced every 24 hours.
Note: for pre-ruminant calves, lambs and kids only.
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Withdrawal times
- For meat: 7 days.
