Description
The combination of amoxycillin and colistin acts additive. Amoxycillin is a semisynthetic broadspectrum penicillin with a bactericidal action against both Gram-positive and Gram-negative bacteria. The spectrum of amoxycillin includes Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase-negative Staphylococcus and Streptococcus, spp. The bactericidal action is due to inhibition of cell wall synthesis.
Amoxicillin is mainly excreted in urine. A major part can also be excreted in bile. Colistin is an antibiotic from the group of polymyxins with a bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella. Since colistin is absorbed for a very small part after oral administration only gastrointestinal indications are relevant.
Indications
Gastrointestinal, respiratory and urinary tract infections caused by amoxicillin and colistin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase negative Staphylococcus and Streptococcus spp. in calves, goats, poultry, sheep and swine.
Contra indications
Hypersensitivity to amoxicillin and/or colistin.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Administration to animals with an active microbial digestion.
Side effects
Hypersensitivity reactions, renal dysfunction, neurotoxicity and neuromuscular blockade.
Dosage
For oral administration:
Calves, goats and sheep:
Twice daily 5 g per 100 kg body weight for 3 - 5 days.
Poultry and swine:
1 kg per 1000 - 2000 litres of drinking water for 3 - 5 days.
Note: for pre-ruminant calves, lambs and kids only.
Please note: Before adding to the drinking water make a presolution of 1 kg Dimoxan WS per 20 litres of water with a temperature of 40 °C.
Withdrawal times
- For meat: 8 days.
