Suspension for oral administration
-
Sulfadiazine
400
mg.
-
Trimethoprim
80
mg.
-
Excipients ad
1
ml.
Description
The combination of trimethoprim and sulfadiazine acts synergistic and usually bactericidal against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result of which a double blockade is accomplished.
Indications
Gastrointestinal and respiratory infections caused by trimethoprim and sulfadiazine sensitive micro-organisms, like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, sheep, goats, poultry and swine.
Contra indications
Hypersensitivity to trimethoprim and/or sulfonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasias.
Side effects
After long-term treatment and high dosages crystalluria can occur.
When symptoms of crystalluria occur (haematuria, kidney colic), treatment has to be stopped immediately and for example sodium carbonate (alkalinises) has to be administered for increasing urine solubility of sulfadiazine. Administration for a prolonged period also increases the risk for blood dyscrasias.
Anaemia, leucopenia and thrombocytopenia.
Dosage
For oral administration:
Calves, goats and sheep : Twice daily 5 ml per 100 kg body weight for 4 - 7 days.
Poultry and swine : 1 litre per 1500 - 2500 litres of drinking water for 4 - 7 days.
Note: for pre-ruminant calves, lambs and kids only. Shake well before use.
Withdrawal times
- For meat:
Calves, sheep, goats and swine : 8 days.
Poultry : 5 days.
Packaging
Bottle of 100, 500 and 1000 ml.
