Description
The combination of trimethoprim and sulfadoxine acts synergistic and usually bactericidal against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result, of which a double blockade is accomplished.
Indications
Gastrointestinal, respiratory and urinary tract infections caused by trimethoprim and sulfadoxine sensitive bacteria, like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.
Contra indications
Hypersensitivity to trimethoprim and/or sulfonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasias.
Side effects
Anaemia, leucopenia and thrombocytopenia.
Dosage
Intramuscular administration:
General: 1 ml per 10 - 15 kg body weight for 3 - 5 days.
Withdrawal times
- For meat : 10 days.
- For milk : 3 days.
