Description
Florfenicol is a bacteriostatic, synthetic broad spectrum antibiotic. It inhibits protein synthesis
in bacterial cells and thus acts against many gram-positive and gram-negative bacteria. In the bacterial protoplasm, it binds to the 70S subunit of the ribosome and thereby inhibits the activity of the enzyme peptidyl transferase. This results in inhibition of protein synthesis on the ribosomes of drug-sensitive bacteria. Florfenicol is a thiamphenicol derivative whose hydroxyl group has been replaced by a fluorine atom. It also increases the effect of the medicine against chloramphenicol-resistant acetyltransferase producing bacteria. Laboratory tests have shown that florfenicol is effective against many pathogenic bacteria isolated from pig infections: Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Pasteurella multocida and poultry diseases such as Enterobacter spp., Escherichia coli, Haemophilus spp., Klebsiella spp., Pasteurella multocida, Proteus spp., Salmonella spp., Staphylococcus spp., Streptococcus spp.
Indications
Treatment of infections caused by microorganisms sensitive to florfenicol in pigs and poultry.
Pigs:
Pleuropneumonia (Actinobacillus pleuropneumoniae), atrophic rhinitis (Pasteurella multocida, Bordetella bronchiseptica), Glässer's disease (Haemophilus parasuis) and other infections caused by florfenicol-susceptible bacteria.
Poultry:
E. coli infections, Pasteurella infections, infectious airway inflammation, staphylococcal
infections; infections caused by Ornithobacterium rhinotracheale and other infections caused by bacteria susceptible to florfenicol.
Contra indications
Do not use in case of hypersensitivity to the active substance or to any of the excipients.
Do not use in case of known resistance to florfenicol.
Do not use in pregnant or lactating sows.
Do not administer to adult boars used for breeding.
Side effects
Pigs: Inflammation of the perianal tissues, rectum, and diarrhoea may occur following administration. These symptoms are temporary and will resolve upon discontinuation of treatment.
Chickens: None known.
Dosage
For oral administration.
The appropriate final dosage should be based on the daily water consumption.
Pigs:
10 ml per 100 kg bodyweight (10 mg/kg body weight) for 5 days.
During treatment, the animals should only drink medicated water.
If this is not possible, the daily dose should be divided into two equal portions, one in the morning, other after 12 hours.
Poultry:
The general daily dose is 20 mg florfenicol per kg bodyweight.
Chickens younger than 4 weeks:
1 litre of product in 1000 litres of drinking water for 3 - 5 days.
Chickens older than 4 weeks:
1 litre of product in 500 litres of drinking water for 3 - 5 days.
Withdrawal times
- For meat and offal:
Pigs : 20 days.
Poultry : 2 days.
Not for use in poultry producing eggs for human consumption.
