Description
The combination of procaine penicillin G and dihydrostreptomycin acts additive and in some cases synergistic. Procaine penicillin G is a small-spectrum penicillin with a bactericidal action against mainly Gram-positive bacteria like Clostridium, Corynebacterium, Erysipelothrix, Listeria, penicillinase-negative Staphylococcus and Streptococcus spp. Dihydrostreptomycin is an aminoglycoside with a bactericidal action against mainly Gram-negative bacteria like E. coli, Campylobacter, Klebsiella, Haemophilus, Pasteurella and Salmonella spp.
Indications
Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin and dihydrostreptomycin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Klebsiella, Listeria, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.
Contra indications
Hypersensitivity to penicillins, procaine and/or aminoglycosides.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
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Side effects
Administration of therapeutic dosages of procaine penicillin G can result in abortion in sows.
Ototoxity, neurotoxicity or nephrotoxicity.
Hypersensitivity reactions.
Dosage
For intramuscular administration:
Cattle:
1 ml per 20 kg body weight for 3 days.
Calves, goats, sheep and swine:
1 ml per 10 kg body weight for 3 days.
Note: Shake well before use and do not administer more than 20 ml in cattle, more than 10 ml in swine and more than 5 ml in calves, sheep and goats per injection site.
Withdrawal times
- For kidney : 45 days.
- For meat : 21 days.
- For milk : 3 days.
