Description
Procaine and benzathine penicillin G are small-spectrum penicillins with a bactericidal action against Gram-positive and Gram-negative bacteria like Campylobacter, Clostridium, Corynebacterium, Erysipelothrix, Haemophilus, Listeria, Pasteurella, penicillinase negative Staphylococcus and Streptococcus spp. After intramuscular administration within 1 to 2 hours therapeutic blood levels are obtained. Because of the slow resorption of benzathine penicillin G, the action is maintained for two days.
Indications
Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, Erysipelothrix, Haemophilus, Listeria, Pasteurella, penicillinase-negative Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.
Contra indications
Hypersensitivity to penicillin and/or procaine.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclins, chloramphenicol, macrolides and lincosamides.
Side effects
With very high overdoses (160.000 IU benzylpenicillin/kg BW) a diminished immune response in swine has been reported.
Administration of therapeutic dosages of procaine penicillin G can result in abortion in sows.
Ototoxity, neurotoxicity or nephrotoxicity.
Hypersensitivity reactions.
Dosage
For intramuscular administration:
Cattle : 1 ml per 20 kg body weight.
Calves, goats, sheep and swine : 1 ml per 10 kg body weight.
This dosage can be repeated after 48 hours when necessary.
Note: Shake well before use and do not administer more than 20 ml in cattle, more than 10 ml in swine and more than 5 ml in calves, sheep and goats per injection site.
Withdrawal times
- For meat : 14 days.
- For milk : 3 days.
