Administration during gestation or to animals with pulmonary and/or cardiac diseases.
Administration to animals with pyometra, since these animals are often hypersensitive to xylazine preparations.

Decreased heart and respiratory rate.
Hypersalivation and vomiting.

Cattle : for intramuscular administration.
dose 1 : 0.25 ml per 100 kg body weight; sedation, small operations.
dose 2 : 0.5 ml per 100 kg body weight; small operations. Animals usually remain standing.
dose 3 : 1 ml per 100 kg body weight; larger operations. Animals lie down.
dose 4 : 1.5 ml per 100 kg body weight; very extensive operations.

Animals have to fast for a couple of hours before administration.

Horses:
4 ml per 100 kg body weight for intravenous administration, or 10 ml per 100 kg body weight for intramuscular administration. With larger operations preferably in combination with other preparations, e.g. intravenous 4 ml per 100 kg body weight and halothane or fluothane as intubation narcosis.

Sheep:
0.15 ml per 10 kg body weight for intramuscular administration.

Dogs:
0.15 ml per kg body weight for intramuscular or intravenous administration. In combination with ketamine: 0.1 ml per kg body weightand 6 - 10 mg ketamine per kg body weight.

Cats:
0.15 ml per kg body weight for intramuscular or subcutaneous administration. In combination with ketamine: 0.1 ml per kg body weight and 6 - 10 mg ketamine per kg body weight.

- For meat : 0 days.
- For milk : 0 days.