Colexil Oral
Enrofloxacin 10% & colistin oral liquid
- Composition
- Colistin sulfate – 1 200 000 IU.
- Enrofloxacin – 100 mg.
Description
The combination of colistin and enrofloxacin has additive action. Enrofloxacin is a synthetic, broad-spectrum antimicrobial substance, belonging to the fluoroquinolone group of antibiotics. Enrofloxacin is active against Gram-negative and Gram-positive bacteria and mycoplasmas. It is well absorbed after oral administration, and rapidly excreted in the bile and urine, mostly as enrofloxacin and the metabolite ciprofloxacin. Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gram-negative bacteria, including E. coli, Haemophilus spp. and Salmonella spp. It is absorbed poorly after oral administration and serum concentrations are generally undetectable in target species. Orally administered colistin is eliminated almost completely in faeces.
Indications
Colexil Oral is indicated for gastrointestinal, respiratory and urinary tract infections caused by colistin- and enrofloxacin-sensitive microorganisms like Campylobacter spp., E. coli, Haemophilus spp., Mycoplasma spp., Pasteurella spp. and Salmonella spp. in swine and poultry.Contra indications
Hypersensitivity to colistin and/or enrofloxacin or to any of the excipients.Administration to animals with seriously impaired renal and/or hepatic functions.
Cases of resistance against quinolones and/or colistin.
Administration to poultry producing eggs for human consumption
Administration to pregnant or lactating animals.
Administration of Colexil Oral in subtherapeutic doses or for prevention.
Side effects
All members of the quinolone family of antibioticshave the ability to cause articular lesions in young animals.
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases, mild diarrhoea or vomiting.
Side effects for quinolones like rash and central nervous system disturbance may occur.
During a period of rapid growth, enrofloxacin may affect joint cartilage.
Dosage
For oral administration through drinking water.Swine:
1 litre per 3000 litres of drinking water for 3 - 5 days.
Poultry:
1 litre per 2000 litres of drinking water for 3 - 5 days.
Only sufficient medicated drinking water should be prepared to cover daily requirements. Medicated drinking water should be replaced every 24 hours.
Withdrawal times
- For meat and offal: 9 days.Not for use in poultry producing eggs for human consumption.
Packaging
Bottle of 100 and 1000 ml.
