Coloxan WS

Doxycycline 10% & colistin water-soluble powder

  • Composition
  • Contains per gram powder:
  • Doxycycline hyclate
    100 mg.
  • Colistin sulfate
    1 200 000 IU.

Description

Doxycycline belongs to the group of tetracyclines and has bacteriostatic action against many Gram-positive and Gram-negative bacteria, like Bordetella spp., Campylobacter spp., E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. Doxycycline is also active against Chlamydia spp., Mycoplasma spp. and Rickettsia spp. The action of doxycycline is based on inhibition of bacterial protein synthesis. Doxycycline has good affinity towards the lungs and is therefore especially useful for treatment of bacterial respiratory infections. Colistin is an antibiotic from the group of polymyxins with bactericidal action against mainly Gram-negative bacteria, like E. coli, Haemophilus spp. and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. Since colistin is absorbed for a very small part after oral administration, only gastrointestinal indications are relevant.

Indications

Gastrointestinal and respiratory infections caused by microorganisms sensitive to doxycycline and/or colistin, like Bordetella spp., Campylobacter spp., Chlamydia spp., E. coli, Klebsiella spp., Haemophilus spp., Mycoplasma spp., Pasteurella spp., Rickettsia spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. in calves, sheep, goats, swine and poultry.

Contra indications

Hypersensitivity to tetracyclines and/or polymyxins.
Administration to animals with seriously impaired renal and/or hepatic functions, animals with an active microbial digestion or animals producing milk or eggs for human consumption.
Concurrent administration of penicillins, cephalosporins, quinolones and cycloserine.

Side effects

Hypersensitivity reactions may occur.
Discolouration of teeth in young animals may occur.
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases or mild diarrhoea.

Dosage

For oral administration.

Calves, sheep and goats:
Twice daily, 1 g per 20 kg body weight for 4 - 5 days.

Swine:
1 kg per 1000 litres of drinking water for 4 - 5 days.

Poultry:
1 kg per 2000 litres of drinking water for 4 - 5 days.

Note: for pre-ruminant calves, lambs and kids only.

Withdrawal times

- For meat:
  Calves, sheep and goats: 14 days.
  Swine: 8 days.
  Poultry: 7 days.

Not for use in poultry producing eggs for human consumption.

Packaging

Sachets of 30 g and 100 g and jar of 1000 g.
Coloxan WS

Product Code:

WDC