Intertrim-480 Oral
Sulfadiazine 40% & trimethoprim 8% oral suspension
- Composition
- Contains per ml:
-
Sulfadiazine400 mg.
-
Trimethoprim80 mg.
Description
The combination of trimethoprim and sulfadiazine has synergistic action and usually bactericidal action against many Gram-positive and Gram-negative bacteria, including E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result of which a double blockade is accomplished.
Indications
Gastrointestinal and respiratory infections caused by trimethoprim- and sulfadiazine-sensitive microorganisms, like E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. in calves, sheep, goats, swine and poultry.
Contra indications
Hypersensitivity to trimethoprim and/or sulfonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasia.
Side effects
After long-term treatment and high dosages crystalluria can occur.When symptoms of crystalluria occur (haematuria, kidney colic), treatment has to be stopped immediately and for example sodium carbonate (alkalinises) has to be administered for increasing urine solubility of sulfadiazine. Administration for a prolonged period also increases the risk for blood dyscrasia.
Anaemia, leukopenia and thrombocytopenia.
Dosage
For oral administration.Calves, sheep and goats:
Twice daily 5 ml per 100 kg body weight for 4 - 7 days.
Swine and poultry:
1 litre per 1500 - 2500 litres of drinking water for 4 - 7 days.
Note: for pre-ruminant calves, lambs and kids only. Shake well before use.
Withdrawal times
- For meat:
Calves, sheep, goats and swine: 8 days.
Poultry: 5 days.
Packaging
