The combination of trimethoprim and sulfadoxine has synergistic and usually bactericidal action against many Gram-positive and Gram-negative bacteria like E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result of which a double blockade is accomplished.
Gastrointestinal, respiratory and urinary tract infections caused by trimethoprim- and sulfadoxine-sensitive bacteria like E. coli, Haemophilus spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. in cattle, calves, sheep, goats and pigs.
Hypersensitivity to trimethoprim and/or sulfonamides.
Administration to animals with a seriously impaired renal and/or hepatic function or with blood dyscrasias.
Anaemia, leukopenia and thrombocytopenia.
For intramuscular and intravenous administration.
General:
1 ml per 10 - 15 kg body weight for 3 - 5 days.