Macrotyl-250 Oral is indicated for the control and treatment of respiratory infections associated with tilmicosin-susceptible microorganisms such as Mycoplasma spp., Pasteurella multocida, Actinobacillus pleuropneumoniae, Actinomyces pyogenes and Mannheimia haemolytica in calves, pigs, chickens and turkeys.

Hypersensitivity or resistance to tilmicosin.
Concurrent administration of other macrolides or lincosamides.
Administration to animals with an active microbial digestion.
Administration to equine or caprine species.
Parenteral administration, especially in porcine species.
During pregnancy and lactation, use only after a risk/benefit assessment by a veterinarian.

Occasionally, a transient reduction in water or (artificial) milk intake has been observed upon treatment with tilmicosin.

For oral administration.

Calves: Twice daily, 1 ml per 20 kg body weight via (artificial) milk for 3 - 5 days.

Pigs: 800 ml per 1000 litres of drinking water (200 ppm) for 5 days.

Poultry: 300 ml per 1000 litres of drinking water (75 ppm) for 3 days.

Note: Medicated drinking water or (artificial) milk should be prepared fresh every 24 h. To ensure a correct dosage, the concentration of the product should be adjusted to the actual fluid intake.

- For meat:
  Calves: 42 days.
   Pigs: 14 days.
  Chickens: 12 days.
  Turkeys: 19 days.

Not for use in poultry producing eggs for human consumption.