Description
The combination of penicillin G and dihydrostreptomycin acts additive and in some cases synergistic. Procaine penicillin G and benzathine penicillin G are small-spectrum penicillins with a bactericidal action against mainly Gram-positive bacteria like Clostridium, Corynebacterium, Erysipelothrix, Listeria, penicillinase-negative Staphylococcus and Streptococcus spp.
Dihydrostreptomycin is an aminoglycoside with a bactericidal action against mainly Gram-negative bacteria like E. coli, Campylobacter, Klebsiella, Haemophilus, Pasteurella and Salmonella spp.
Indications
Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin and dihydrostreptomycin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Klebsiella, Listeria, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp.
Contra indications
Hypersensitivity to penicillins, procaine and/or aminoglycosides.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Side effects
With very high overdoses (160.000 IU benzylpenicillin/kg BW) a diminished immune response in swine has been reported.
Administration of therapeutic dosages of procaine penicillin G can result in abortion in sows.
Ototoxity, neurotoxity or nephrotoxicity.
Hypersensitivity reactions.
Dosage
For intramuscular administration:
General: 1 ml per 10 kg body weight every 72 hours.
When recommended by professional opinion, it can be administrated every 48 hours.
Note: Shake well before use and do not administer more than 20 ml in cattle, more than 10 ml in swine and more than 5 ml in calves, sheep and goats per injection site.
Withdrawal times
- For kidney : 45 days.
- For meat : 30 days.
- For milk : 5 days.
