Piperazine is an anthelmintic with activity against nematodes. It induces a reversible flaccid paralysis in the nematode parasites. This is provoked by hyperpolarisation of the cell membrane followed by suppression of spontaneous spike potentials. The paralysed nematodes are subsequently expelled from the gut lumen by normal peristaltic actions.
Hypersensitivity to piperazine.
Administration to animals with a seriously impaired renal and/or hepatic function.
- For meat: 2 days.
- For eggs: 2 days.