Coli-2400 Oral

Colistin 2400 IU oral liquid

  • Composition
  • Contains per ml:
  • Colistin sulfate
    2 400 000 IU.

Description

Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gram-negative bacteria, like E. coli, Haemophilus spp. and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. They disorganise the outer membrane of Gram-negative bacteria by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the anionic lipid A region, thereby neutralising the endotoxin capacity of LPS. Colistin sulfate is poorly absorbed after oral administration, and serum concentrations are generally undetectable. In chickens, residues in serum were detectable for up to 6 hours after administration in the drinking water. Orally administered colistin is eliminated almost totally in faeces.

Indications

Coli-2400 Oral is indicated for gastrointestinal infections caused by colistin-sensitive microorganisms like E. coli, Haemophilus spp. and Salmonella spp. in calves, sheep, goats, swine and poultry.

Contra indications

Cases of hypersensitivity to colistin and/or any of the excipients.
Administration to animals with seriously impaired renal functions or with an active microbial digestion.
Administration in subtherapeutic doses or in cases of resistance to colistin.

Side effects

Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases or mild diarrhoea. Overdoses may result in renal failure.

Dosage

For oral administration.

Calves, sheep and goats:
Twice daily 1 ml per 40 kg body weight for 5 - 7 days.

Swine and poultry:
1 litre per 2000 - 4000 litres of drinking water for 5 - 7 days.

Only sufficient medicated drinking water should be prepared to cover daily requirements. Medicated drinking water should be replaced every 24 hours.

Note: for pre-ruminant calves, lambs and kids only.

Withdrawal times

- For meat: 7 days.

Packaging

Bottle of 1000 ml.
Coli-2400 Oral

Product Code:

OC24