Dimoxan WS

Amoxicillin 20% & colistin water-soluble powder

  • Composition
  • Contains per gram powder:
  • Amoxicillin trihydrate
    200 mg.
  • Colistin sulfate
    1 200 000 IU.

Description

The combination of amoxicillin and colistin has additive action. Amoxicillin is a semisynthetic broad-spectrum penicillin with a bactericidal action against both Gram-positive and Gram-negative bacteria. The spectrum of amoxicillin includes Campylobacter spp., Clostridium spp., Corynebacterium spp., E. coli, Erysipelothrix spp., Haemophilus spp., Pasteurella spp., Salmonella spp., penicillinase-negative Staphylococcus spp. and Streptococcus spp. The bactericidal action is due to inhibition of cell wall synthesis. Amoxicillin is mainly excreted in urine. A major part can also be excreted in bile. Colistin is an antibiotic from the group of polymyxins with a bactericidal action against Gram-negative bacteria, like E. coli, Haemophilus spp. and Salmonella spp. Since colistin is absorbed for a very small part after oral administration, only gastrointestinal indications are relevant.

Indications

Gastrointestinal, respiratory and urinary tract infections caused by amoxicillin- and colistin-sensitive microorganisms, like Campylobacter spp., Clostridium spp., Corynebacterium spp., E. coli, Erysipelothrix spp., Haemophilus spp., Pasteurella spp., Salmonella spp., penicillinase-negative Staphylococcus spp. and Streptococcus spp. in calves, sheep, goats, swine and poultry.

Contra indications

Hypersensitivity to amoxicillin and/or colistin.
Administration to animals with a seriously impaired renal function.
Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
Administration to animals with an active microbial digestion.

Side effects

Hypersensitivity reactions, renal dysfunction, neurotoxicity and neuromuscular blockade.

Dosage

For oral administration.

Calves, sheep and goats:
Twice daily, 5 g per 100 kg body weight for 3 - 5 days.

Swine and poultry:
1 kg per 1000 - 2000 litres of drinking water for 3 - 5 days.

Note: for pre-ruminant calves, lambs and kids only. Before adding to the drinking water make a presolution of 1 kg Dimoxan WS per 20 litres of water with a temperature of 40 °C.

Withdrawal times

- For meat: 8 days.

Not for use in poultry producing eggs for human consumption.

Packaging

Sachet of 100 g and jar of 1000 g.
Dimoxan WS

Product Code:

WAC