Pen-N
Procaine pen G & neomycin injection
- Composition
- Procaine penicillin G – 200 000 IU.
- Neomycin sulfate – 100 mg.
Description
The combination of procaine penicillin G and neomycin has additive action and, in some cases, synergistic action. Procaine penicillin G is a narrow-spectrum penicillin with bactericidal action against mainly Gram-positive bacteria like Corynebacterium spp., Listeria spp., Clostridium spp., Erysipelothrix spp., Streptococcus spp. and Staphylococcus spp. It acts by inhibition of bacterial cell wall synthesis in actively growing bacteria. Neomycin is an aminoglycoside with bactericidal action against mainly Gram-negative bacteria like E. coli, Klebsiella spp., Salmonella spp. and Pasteurella spp. Its action is based on inhibition of bacterial protein synthesis.
Indications
Pen-N is indicated for the therapeutic treatment of arthritis and mastitis and for the therapeutic treatment of gastrointestinal, respiratory and urinary tract infections caused by penicillin- and neomycin-sensitive microorganisms like Campylobacter spp., Clostridium spp., Corynebacterium spp., E. coli, Erysipelothrix spp., Haemophilus spp., Klebsiella spp., Listeria spp., Pasteurella spp., Salmonella spp., Staphylococcus spp. and Streptococcus spp. in cattle, calves, sheep and swine.
Contra indications
Hypersensitivity to penicillin and/or aminoglycosides.Administration to animals with an impaired renal function.
Concurrent administration of nephrotoxic substances or anaesthetics.
Side effects
Occasionally in suckling and fattening pigs, administration of this product may cause a transient pyrexia, vomiting, shivering, listlessness and incoordination. Additionally in pregnant sows and gilts, a vulval discharge, which could be associated with abortion, has been reported.Ototoxicity and nephrotoxicity.
Hypersensitivity reactions.
Dosage
Shake well before use.For intramuscular administration.
The general dosage rate is 1 ml per 20 kg body weight, daily, for 3 days.
Do not administer more than 20 ml in cattle, more than 5 ml in calves and sheep or more than 10 ml in swine per injection site.
Withdrawal times
Meat and offal:- Cattle and calves: 89 days.
- Sheep: 62 days.
- Swine: 50 days.
Milk:
- Cattle: 5 days.
Not for use in sheep producing milk for human consumption.
Packaging
Bottle of 100 ml.
