Diminazene aceturate belongs to the group of aromatic diamidines, and has activity against trypanosomiasis, babesiosis, theileriosis and mixed haemoprotozoan infections.
Tryponil RTU is indicated for the therapeutic treatment and prophylaxis of trypanosomiasis, babesiosis, mixed haemoprotozoan infections and theileriosis in horses, cattle, buffalos, sheep, goats and dogs.
Administration to animals with known hypersensitivity to diminazene and/or phenazone
Administration to animals with an impaired renal and/or hepatic function
Administration of the product to camels
After overdosing or repeated dosing, toxic disturbances of the central nervous system may develop (salivation, sweating, tremors).
In rare cases, multiple therapeutic doses can produce severe nervous signs and prominent haemorrhagic and malacic lesions of the cerebellum and thalamus in cattle and dogs.
After multiple therapeutic doses, degenerative fatty changes can occur in liver, kidneys, myocardium and muscles.
For deep intramuscular administration.
The usual therapeutic dose is 1 ml per 20 kg body weight (3.5 mg/kg). For infections with T. brucei, T. evansi and Theileria annulata, this dose should be doubled (1 ml per 10 kg).
For infections due to resistant strains, the dose may be increased to 8 mg/kg body weight (1 ml per 8.75 kg).
Do not exceed a total dose of 4 g (57 ml) per animal. When large quantities of Tryponil RTU solution are administered, it is advisable to divide the amount to be injected over multiple sites in order to avoid local pain reactions.
- For meat: 21 days.
- For milk: 3 days.