Fluconix-340
Nitroxinil 34% injection
- Composition
- Nitroxinil – 340 mg.
Description
The main pharmacological action of the active ingredient in Fluconix-340, nitroxinil, is fasciolicidal. The lethal action against Fasciola hepatica has been demonstrated in vitro and in vivo in laboratory animals, and in sheep and cattle. The mechanism of action is due to uncoupling of oxidative phosphorylation. It is also active against triclabendazole-resistant F. hepatica.
Indications
Fluconix-340 is indicated for the treatment of fascioliasis (infestations of mature and immature Fasciola hepatica) in cattle and sheep. It is also effective, at the recommended dose rate, against adult and larval infestations of Haemonchus contortus in cattle and sheep and Haemonchus placei, Oesophagostomum radiatum and Bunostomum phlebotomum in cattle.
Contra indications
Do not use in animals with known hypersensitivity to the active ingredient.
Do not use in animals producing milk for human consumption.
Do not exceed stated dose.
Side effects
Small swellings are occasionally observed at the injection site in cattle. These can be avoided by injecting the dose in two separate sites and massaging well to disperse the solution. No systemic ill effects are to be expected when animals (including pregnant cows and ewes) are treated at normal dosage.
Special precautions:
Ensure the injection does not enter subcutaneous muscle. On farms with fluke-infested pastures, routine preventative dosing should be carried out at intervals of not less than one month, having regard for such factors as the past disease history of the farm, the frequency and severity of neighbouring outbreaks and regional forecasts or incidence.
Dosage
For subcutaneous administration.The standard dosage is 10 mg nitroxinil per kg body weight.
1.5 ml of Fluconix-340 per 50 kg of body weight.
Both infected and in-contact animals should be treated, treatment being repeated as considered necessary, though not more frequently than once per month. Dairy cows should be treated at drying off (at least 28 days before calving).
Administer according to the following doses scale:
14 - 20 kg 0.5 ml
21 - 30 kg 0.75 ml
31 - 40 kg 1.0 ml
41 - 55 kg 1.5 ml
56 - 75 kg 2.0 ml
> 75 kg 2.5 ml
In outbreaks of fascioliasis each sheep in the flock should be injected immediately when the presence of the disease is recognised, repeating treatment as necessary throughout the period when infestation is occurring, at intervals of not less than one month.
Withdrawal times
- For meat:Cattle: 60 days.
Sheep: 49 days.
Not for use in animals producing milk for human consumption.
Packaging
